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KMID : 1134819990280030698
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 3 p.698 ~ p.704
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The Radioprotective Effect of Kuei - Pi - Tang as a Prescription of Traditional Chinese Medicine in Mice
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Kim Seong-Ho
Lee Song-Eun
Oh Heon
Yang Jung-Ah
Chung Chi-Young
Jang Jong-Sik
Yu Young-Bub
Jo Sung-Kee
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Abstract
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In this study, we evaluated the radioprotective effects of Kuei-Pi-Tang and its ingredients, as a prescription of traditional Oriental medicine. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low dose of γ -rays. In the mice administered with Kuei-Pi-Tang extract before irradiation, the jejunal crypts were protected significantly(p＜0.005) and the frequency of radiation-induced apoptosis was reduced(p＜0.05). In the experiment on the effects of the ingredients of Kuei-Pi-Tang, the results indicated that the extract of Dangui(Angelica sinensis), Suanzaoren(Zizyphus valgaris), Rensan(Panax ginseng), Fuling(Poria cocos) and Muxiang(Saussurea lappa) might have a major radioprotective effect. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indicated that Kuei-Pi-Tang might be a useful radioprotector, especially since it is a relatively nontoxic natural product.
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KEYWORD
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radioprotective, Kuei-Pi-Tang, Oriental medicine, jejunal crypt, spleen colony
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